Endocrine Abstracts

Recent research has suggested mild hypocortisolism in at least some subjects with Chronic Fatigue Syndrome (CFS). For example, our study of 120 well-characterised CFS patients showed a significant reduction in 24-h urinary free cortisol (UFC). Studies of the HPA axis suggest a generally impaired responsivity to challenge, although there is no one specific pattern. Examples include impaired responses to CRH challenge. A randomised, placebo controlled trial of low dose (5-10 mg/...